Whether from music or machinery, Manchester has always been a city with a beat, and you’ll feel the anti-establishment spirit as you roam. Once you’ve had your fill of main sights in the City Centre, make time for the Northern Quarter, a rapidly developing neighborhood like no other in town. It’s here where the city’s artists and makers come most dramatically alive through indie shops, restaurants helmed by local chefs, and bars pushing the craft-cocktail scene forward. If you’re keen to spend an afternoon digging for vintage clothing or ‘70s vinyls, this is the place to do it. Most items aren’t found anywhere else on Earth—just remember to leave room in your suitcase.